| Property |
Details |
| Chemical Name |
Diclofenac Sodium |
| CAS Number |
15307 - 79 - 6 |
| Molecular Formula |
C14H9Cl2NNaO2 |
| Molecular Weight |
318.12 g/mol |
| Appearance |
Usually appears as a white to off - white crystalline powder |
| Melting Point |
Around 283 - 285 °C |
| Solubility |
Sparingly soluble in water. Soluble in organic solvents like ethanol, methanol, and acetone. Solubility in water can be improved by forming salt - based solutions. |
| Odor |
Odorless |
| pKa Value |
The pKa of diclofenac (the acidic form before forming the sodium salt) is approximately 4.0. This value is important as it affects the drug's ionization state in different pH environments within the body. In the acidic environment of the stomach, it exists mainly in its non - ionized form, which can enhance its absorption through the lipid - rich cell membranes. |
| Chemical Structure |
It has a benzene ring with a 2,6 - dichlorophenyl group and an amino - substituted phenylacetic acid moiety. The sodium ion is associated with the carboxylate group of the phenylacetic acid, forming the sodium salt. The presence of the chlorine atoms on the benzene ring and the overall structure contribute to its pharmacological activity. |
| Stability |
Should be stored in a tightly closed container, protected from light and moisture. Under normal storage conditions (room temperature, away from direct sunlight and humidity), it is relatively stable. However, exposure to extreme heat, humidity, or strong oxidizing agents may lead to degradation over time. |
| Pharmacological Class |
Non - steroidal anti - inflammatory drug (NSAID) |
| Synonyms |
Sodium 2 - [(2,6 - dichlorophenyl) amino]acetate; Voltaren (a well - known brand name) |
1. Treatment of Arthritis and Joint Pain
- Diclofenac sodium is widely used for various types of arthritis. In rheumatoid arthritis, it helps to reduce the inflammation in the joints, which is characterized by swelling, pain, and stiffness. By inhibiting the enzyme cyclooxygenase (COX), it blocks the synthesis of prostaglandins, which are key mediators of inflammation. In a study involving patients with rheumatoid arthritis, treatment with diclofenac sodium significantly reduced the number of tender and swollen joints. The usual oral dose for adults with rheumatoid arthritis is often in the range of 75 - 150 mg per day, divided into multiple doses.
- For osteoarthritis, which is the most common form of arthritis and is due to wear and tear of the joints over time, diclofenac sodium can alleviate pain and improve joint function. It can be administered orally, topically as a gel or cream, or as an injection in some cases. Topical formulations are especially useful for patients who cannot tolerate the systemic side effects of oral medications. For example, applying a diclofenac - containing gel to the affected knee or hand joints can provide local relief of pain and inflammation.
- In gouty arthritis, where there is an accumulation of uric acid crystals in the joints causing severe pain and inflammation, diclofenac sodium can be used as part of the treatment regimen. It helps to reduce the acute inflammation associated with gout attacks, providing rapid relief to the patient. The anti - inflammatory action of diclofenac sodium also helps in reducing the redness and swelling around the affected joints.
- It is also effective in treating other types of joint - related disorders such as ankylosing spondylitis (a type of spinal arthritis) and psoriatic arthritis. In ankylosing spondylitis, it can relieve the pain and stiffness in the spine, improving the patient's mobility and quality of life. For psoriatic arthritis, which is associated with psoriasis (a skin condition), diclofenac sodium can reduce both the joint symptoms and, in some cases, have a positive impact on the skin manifestations due to its anti - inflammatory properties.
2. Management of Soft - Tissue Pain
- Diclofenac sodium is effective in treating non - joint soft - tissue pain. For example, in cases of tendonitis (inflammation of the tendons), such as tennis elbow (lateral epicondylitis) or golfer's elbow (medial epicondylitis), it can reduce the pain and inflammation in the affected tendons. Oral or topical formulations can be used. Topical application directly to the area of the tender tendon can provide targeted relief.
- In bursitis (inflammation of the bursae, small fluid - filled sacs that cushion the joints), diclofenac sodium helps to reduce the swelling and pain around the joint. Whether it is shoulder bursitis or knee bursitis, the drug can be administered in different forms depending on the severity of the condition. In mild cases, topical gels or creams may be sufficient, while more severe cases may require oral or injectable forms.
- Muscle pain, such as that caused by muscle strains, sprains, or overexertion during exercise, can also be alleviated with diclofenac sodium. It helps to reduce the inflammation in the muscle tissue and relieve the associated pain. For example, athletes who experience muscle soreness after intense training can use diclofenac - containing products to speed up their recovery. The oral form is commonly used for muscle pain, but in some cases, topical patches may also be prescribed for localized pain relief.
3. Relief of Acute Pain
- In the case of post - surgical pain, diclofenac sodium is often used as part of the pain management strategy. It can be given orally, intravenously, or as a suppository depending on the type of surgery and the patient's condition. For minor surgeries like dental extractions, oral diclofenac sodium tablets can effectively relieve the pain. In more major surgeries, intravenous or intramuscular injections may be used in the immediate post - operative period to provide rapid pain relief.
- Trauma - related pain, such as that from fractures, cuts, or bruises, can also be managed with diclofenac sodium. It helps to reduce the pain and inflammation at the site of injury. For example, patients with a broken bone may be prescribed diclofenac sodium to manage the pain during the healing process. The drug can also help in reducing the swelling associated with the trauma, which can further aid in the recovery of the injured area.
- Primary dysmenorrhea (painful periods) is another area where diclofenac sodium is commonly used. It can significantly reduce the intensity of menstrual cramps by inhibiting the production of prostaglandins in the uterus. Prostaglandins are responsible for the contractions of the uterine muscles, and by reducing their levels, diclofenac sodium can relieve the pain. The recommended dose for primary dysmenorrhea is usually 50 - 150 mg per day, taken in divided doses starting from the onset of menstruation.
4. Ophthalmic Applications
- Diclofenac sodium ophthalmic solutions are used for various eye conditions. In uveitis (inflammation of the uvea, the middle layer of the eye), it helps to reduce the inflammation, preventing damage to the eye structures such as the iris and ciliary body. By reducing the production of inflammatory mediators in the eye, it can relieve symptoms such as eye pain, redness, and sensitivity to light.
- After cataract surgery or other intraocular surgeries, diclofenac sodium ophthalmic drops are often prescribed to prevent and treat inflammation. It can also inhibit the formation of posterior capsule opacification (a common complication after cataract surgery) to some extent. In addition, for corneal injuries or abrasions, diclofenac sodium ophthalmic solutions can help reduce pain and inflammation, promoting the healing process of the cornea.
5. Other Applications
- In some cases, diclofenac sodium may be used in veterinary medicine to treat pain and inflammation in animals. For example, in horses with joint problems or soft - tissue injuries, it can be administered in appropriate doses to relieve pain and improve mobility. However, the use in animals requires careful consideration of the species, weight, and overall health of the animal.
- In research settings, diclofenac sodium is sometimes used as a tool to study the role of prostaglandin synthesis and inflammation in various biological processes. It can be used in cell culture experiments or animal models to investigate the mechanisms of inflammation - related diseases and to test the efficacy of new drugs or treatment strategies that target the inflammatory pathway.
Q1: Can I get some samples?
A: Yes, sure. Usually, we can provide free samples for less than 5 kg, but the customer needs to pay for the shipping.
Q2: What is your MOQ?
A: The minimum order quantity varies for different products, with most requiring a minimum of 1 ton. However, we can accommodate smaller quantities, such as 100kg, with a 100% sample charge.
Q3: How to confirm product quality before placing an order?
A: You can obtain free samples of the products, but you need to cover the shipping fee or arrange for the samples to be sent to us by express. Additionally, you can provide us with your product specifications and requirements, and we will manufacture the products accordingly.
Q4: Is there a discount for bulk purchases? How much is the discount?
A: Yes, we offer discounts for bulk purchases. The discount is determined by evaluating factors such as purchase volume, product type, and cooperation period. Generally, the larger the purchase volume, the greater the discount.
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A: Payment can be made by wire transfer, Western Union, PayPal, Visa, Mastercard, T/T, Apple Pay, Google Pay, etc.
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A: We ship the products out within 1-3 days and provide a tracking number. Shipping time varies by country.
Q7: What qualifications and certifications does the company have? Such as ISO certification, etc.
A: Our supply manufacturers hold several authoritative certifications to ensure our products and services meet international standards and industry regulations. This includes the ISO 9001 Quality Management System certification, which indicates we have reached internationally recognized levels in product quality control, production process management, and continuous improvement, providing stable and reliable quality assurance for customers.
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A: After purchasing products from our company, you will be supported by our professional technical team and after-sales team, who will help solve any problems you may encounter.
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