Reliable Source for Resellers Ethyl 2- ((5-chloropyridin-2-yl)amino) -2-Oxoacetate Hydrochloride (HCl) CAS 15307-79-6

• Customization: Available
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Model NO.: yh-ydsbzz
• Grade Standard: Industrial Grade
• Purity: 99%
• Environmental Protection: Yes
• Freight1: Small Quantity Logistics or Air Transport
• Freight2: Pick up
• Freight3: Ocean Freight
• Free Sample: Available
• Belong: Yuhan Chem
• Lead Time: Within 7 Days
• Storagemethod: Sealed Container
• Packaging: Sealed Packaging
• Odor: Odorless
• MOQ: 1kg
• Port1: Chongqing
• Storage2: Cool Dry Place
• Stability: Excellent
• Transport Package: 1kg Minimum Order Quantity
• Specification: Sealing, on request
• Trademark: Customizable
• Origin: China
• HS Code: 29333990
• Production Capacity: 10000ton/Year

Product Description

Product Parameters

 

Property	Details
Chemical Name	Ethyl 2 - ((5 - chloropyridin - 2 - yl)amino)-2 - oxoacetate hydrochloride
CAS Number	1243308 - 37 - 3
Molecular Formula	C8H9Cl2N2O3
Molecular Weight	253.07 g/mol
Appearance	Usually appears as a white to off - white crystalline powder. However, the appearance can be affected by factors such as purity and preparation methods.
Melting Point	Specific melting point data may vary depending on the compound's purity. Generally, it is expected to have a characteristic melting point within a certain range, which is an important physical property for identification and quality control.
Solubility	Soluble in polar solvents such as water and some alcohols. The presence of the hydrochloride salt enhances its solubility in aqueous media due to the formation of ionic interactions. In water, it dissociates into its cationic and anionic components, which can influence its behavior in solution, such as its chemical reactivity and ability to participate in chemical reactions.
Odor	Odorless or may have a very faint, characteristic odor. The lack of a strong odor is common for many organic salts and is an important aspect for its handling and use, especially in pharmaceutical and chemical applications where odor can be a factor in product formulation and acceptance.
Chemical Structure	The molecule consists of an ethyl 2 - oxoacetate moiety linked to a 5 - chloropyridin - 2 - amine group. The hydrochloride salt is formed by the addition of a hydrochloric acid molecule, which protonates the nitrogen atom in the amine group. This structural feature is crucial for its chemical properties and reactivity. The chlorine atom on the pyridine ring and the carbonyl and ester functional groups in the oxoacetate part contribute to its overall chemical behavior, such as its ability to participate in nucleophilic substitution reactions and hydrogen bonding interactions.
Stability	Under normal storage conditions (room temperature, protected from light, moisture, and strong oxidizing or reducing agents), it is relatively stable. However, exposure to high temperatures, humidity, or extreme pH conditions may lead to degradation. For example, in the presence of strong bases, the ester group may undergo hydrolysis, and under acidic conditions with strong oxidizing agents, the pyridine ring or other parts of the molecule may be oxidized.
pKa Value	The pKa value of the compound is relevant for understanding its behavior in different pH environments. The amine group in the molecule can be protonated or deprotonated depending on the pH of the solution. The pKa value helps to determine the degree of ionization of the compound, which in turn affects its solubility, chemical reactivity, and interactions with other molecules. For example, at a pH lower than its pKa, the amine group will be mostly protonated, increasing the overall positive charge of the molecule and potentially enhancing its solubility in polar solvents.
Synonyms	There may be other names used in different research or industrial contexts, which can be important for cross - referencing in scientific literature and regulatory documents.

 

Product Description

  

• Impurity Studies for Edoxaban:
  • Edoxaban is an anticoagulant drug. Ethyl 2 - ((5 - chloropyridin - 2 - yl)amino)-2 - oxoacetate hydrochloride serves as an impurity in the synthesis and production of edoxaban. Understanding the behavior and properties of this impurity is crucial for ensuring the quality, safety, and efficacy of edoxaban pharmaceutical products. In pharmaceutical manufacturing, strict control over impurities is essential. By studying this impurity, researchers can develop better synthesis routes for edoxaban to minimize its formation. For example, if the impurity is formed during a particular reaction step in edoxaban synthesis, modifying the reaction conditions such as temperature, reaction time, or choice of reagents can be explored to reduce its yield.
  • It is also used in the development of analytical methods for edoxaban. Analytical chemists need to be able to detect and quantify this impurity accurately in edoxaban drug samples. High - performance liquid chromatography (HPLC) and mass spectrometry (MS) techniques are often employed. The impurity is used to calibrate these analytical instruments, ensuring that they can precisely measure the amount of the impurity present in edoxaban formulations. This helps in setting appropriate impurity limits in drug quality control specifications.
• Medicinal Chemistry Studies:
  • The compound's structure can be a starting point for designing new drugs. The unique combination of the 5 - chloropyridin - 2 - amine and 2 - oxoacetate moieties may exhibit interesting biological activities. Medicinal chemists can modify the structure by substituting different groups on the pyridine ring or the oxoacetate part to create analogs. These analogs can then be screened for various biological activities such as antibacterial, antifungal, or anti - inflammatory properties. For example, changing the position or nature of the substituent on the pyridine ring may affect the compound's ability to interact with specific biological targets, leading to the discovery of new lead compounds for drug development.
  • It can also be used as a reference compound in structure - activity relationship (SAR) studies. By comparing the biological activities of this compound with its analogs, researchers can identify which parts of the molecule are crucial for a particular activity. This information can guide the rational design of more potent and selective drugs.

 

2. In Chemical Synthesis

 

• Building Block for Organic Synthesis:
  • Ethyl 2 - ((5 - chloropyridin - 2 - yl)amino)-2 - oxoacetate hydrochloride can act as a valuable building block in organic synthesis. The various functional groups present in the molecule, such as the amine, carbonyl, and ester groups, can participate in a wide range of chemical reactions. For instance, the ester group can undergo hydrolysis to form the corresponding carboxylic acid, which can then be further reacted with other reagents to form amides, esters, or other derivatives. The amine group can be used in coupling reactions with electrophiles to introduce new functional groups or to build more complex molecular structures.
  • In the synthesis of heterocyclic compounds, the pyridine ring of the compound can be incorporated into new ring systems. For example, through a series of reactions involving cyclization and condensation, it can be used to synthesize fused - ring heterocycles that may have potential applications in materials science or as ligands in coordination chemistry.
• Reagent in Chemical Reactions:
  • It can serve as a reagent in specific chemical reactions. For example, in certain nucleophilic substitution reactions, the chlorine atom on the pyridine ring can be replaced by other nucleophiles. This reaction can be used to introduce new functional groups or to modify the molecular structure in a desired way. The reaction conditions, such as the choice of solvent, temperature, and the nature of the nucleophile, need to be carefully optimized to achieve high yields and selectivity. In addition, the compound can participate in reactions involving the carbonyl group, such as aldol - type reactions or reduction reactions, which can lead to the formation of new carbon - carbon bonds or the transformation of the carbonyl group into other functional groups.

 

 

 

 

Detailed Photos

 

 

Certifications

Packaging & Shipping

 

Our Advantages

 

Company Profile

FAQ

Q1: Can I get some samples?
A: Yes, sure. Usually, we can provide free samples for less than 5 kg, but the customer needs to pay for the shipping.

Q2: What is your MOQ?
A: The minimum order quantity varies for different products, with most requiring a minimum of 1 ton. However, we can accommodate smaller quantities, such as 100kg, with a 100% sample charge.

Q3: How to confirm product quality before placing an order?
A: You can obtain free samples of the products, but you need to cover the shipping fee or arrange for the samples to be sent to us by express. Additionally, you can provide us with your product specifications and requirements, and we will manufacture the products accordingly.

Q4: Is there a discount for bulk purchases? How much is the discount?
A: Yes, we offer discounts for bulk purchases. The discount is determined by evaluating factors such as purchase volume, product type, and cooperation period. Generally, the larger the purchase volume, the greater the discount.

Q5: How do I start paying?
A: Payment can be made by wire transfer, Western Union, PayPal, Visa, Mastercard, T/T, Apple Pay, Google Pay, etc.

Q6: What is the shipping time?
A: We ship the products out within 1-3 days and provide a tracking number. Shipping time varies by country.

Q7: What qualifications and certifications does the company have? Such as ISO certification, etc.
 A: Our supply manufacturers hold several authoritative certifications to ensure our products and services meet international standards and industry regulations. This includes the ISO 9001 Quality Management System certification, which indicates we have reached internationally recognized levels in product quality control, production process management, and continuous improvement, providing stable and reliable quality assurance for customers.

Q8: How about the after-sale service of products?
A: After purchasing products from our company, you will be supported by our professional technical team and after-sales team, who will help solve any problems you may encounter.