High Purity and High Quality Hot Selling Pharmaceutical Intermediates Pharmaceutical Catalysis 2-Dicyclohexylphosphino-2′, 4′, 6′-Triisopropylbiphenyl/X-Phos

• Customization: Available
• Type: Biphenylphosphine Compounds
• Appearance: Powder
• Model NO.: yh-2ehyjl
• Grade Standard: Industrial Grade
• CAS No: 564483-18-7
• Hf: C33h49p
• Purity: 98%
• Free Sample: Available
• Environmental Protection: Yes
• Belong: Yuhan Chem
• Lead Time: Within 7 Days
• Storagemethod: Sealed Container
• Freight: Air, Sea, Train, Self-Collection
• Packaging: Sealed Packaging
• Odor: Odorless
• Storage2: Cool Dry Place
• Stability: Excellent
• Port Add: Chongqing
• MOQ: 1kg
• Transport Package: 1kg Minimum Order Quantity
• Specification: High purity and high quality
• Trademark: Customizable
• Origin: China
• HS Code: 2902909090
• Production Capacity: 10000ton/Year

Product Description

Product Parameters

  

Property	Value
CAS Number	564483-18-7
Molecular Formula	C33H49P
Molecular Weight	476.72
English Name	2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl
English Synonyms	X-Phos, 2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl
Appearance	White crystalline powder
Melting Point	187-190°C
Boiling Point	569.8°C at 760 mmHg
Solubility	Soluble in common organic solvents
Storage Conditions	Store in a cool, dry place, preferably under inert gas
Safety Information	Irritant; avoid contact with air and moisture

Product Description

 

Usage of 2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl (X-Phos, CAS Number: 564483-18-7)

X-Phos is a highly versatile and air-stable phosphine ligand that is widely used in various catalytic reactions, particularly in palladium-catalyzed cross-coupling reactions. Here are some of its key applications:

1. Palladium-Catalyzed Cross-Coupling Reactions:
   • Suzuki-Miyaura Coupling: X-Phos is used as a ligand in Suzuki-Miyaura cross-coupling reactions, which are essential for forming carbon-carbon bonds.
   • Negishi Coupling: It is used in Negishi coupling reactions, particularly for the coupling of 2-heterocyclic organozinc reagents.
   • Stille Coupling: X-Phos is effective in Stille coupling reactions, which involve the formation of carbon-carbon bonds.
2. Amination and Amidation Reactions:
   • Pd-Catalyzed Amination: X-Phos is an exceptional ligand for palladium-catalyzed amination and amidation of aryl sulfonates.
   • Chemoselective Amination: It is used for the chemoselective amination of aryl chlorides.
3. Other Applications:
   • Carbonyl Enolate Coupling: X-Phos is used in carbonyl enolate coupling reactions.
   • Borylation of Aryl Chlorides: It is used for the palladium-catalyzed borylation of aryl chlorides to form trifluoroborates.
   • Three-Component Synthesis of Indoles: X-Phos is used in the palladium-catalyzed three-component synthesis of indoles.
   • Direct Arylation: It is used for the direct arylation of picoline N-oxide.

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FAQ

Q1: Can I get some samples?
A: Yes, sure. Usually, we can provide free samples for less than 5 kg, but the customer needs to pay for the shipping.

Q2: What is your MOQ?
A: The minimum order quantity varies for different products, with most requiring a minimum of 1 ton. However, we can accommodate smaller quantities, such as 100kg, with a 100% sample charge.

Q3: How to confirm product quality before placing an order?
A: You can obtain free samples of the products, but you need to cover the shipping fee or arrange for the samples to be sent to us by express. Additionally, you can provide us with your product specifications and requirements, and we will manufacture the products accordingly.

Q4: Is there a discount for bulk purchases? How much is the discount?
A: Yes, we offer discounts for bulk purchases. The discount is determined by evaluating factors such as purchase volume, product type, and cooperation period. Generally, the larger the purchase volume, the greater the discount.

Q5: How do I start paying?
A: Payment can be made by wire transfer, Western Union, PayPal, Visa, Mastercard, T/T, Apple Pay, Google Pay, etc.

Q6: What is the shipping time?
A: We ship the products out within 1-3 days and provide a tracking number. Shipping time varies by country.

Q7: What qualifications and certifications does the company have? Such as ISO certification, etc.
 A: Our supply manufacturers hold several authoritative certifications to ensure our products and services meet international standards and industry regulations. This includes the ISO 9001 Quality Management System certification, which indicates we have reached internationally recognized levels in product quality control, production process management, and continuous improvement, providing stable and reliable quality assurance for customers.

Q8: How about the after-sale service of products?
A: After purchasing products from our company, you will be supported by our professional technical team and after-sales team, who will help solve any problems you may encounter.